LymphedemaV1, Main, Exploration, bibRecord, 00A195

Sentinel node biopsy in early vulvar cancer

Identifieur interne : 00A195 ( Main/Exploration ); précédent : 00A194; suivant : 00A196

Sentinel node biopsy in early vulvar cancer

Auteurs : C De Cicco [Italie] ; M. Sideri ; M. Bartolomei [Italie] ; C. Grana [Italie] ; M. Cremonesi [Italie] ; M. Fiorenza [Italie] ; A. Maggioni ; L. Bocciolone ; C. Mangioni [Italie] ; N. Colombo ; G. Paganelli [Italie]

Source :

British Journal of Cancer [ 0007-0920 ] ; 2000.

RBID : PMC:2363267

Abstract

Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This study evaluates the feasibility of the surgical identification of sentinel groin nodes using lymphoscintigraphy and a gamma-detecting probe in patients with early vulvar cancer. Technetium-99m-labelled colloid human albumin was administered perilesionally in 37 patients with invasive epidermoid vulvar cancer (T1–T2) and lymphoscintigraphy performed the day before surgery. An intraoperative gamma-detecting probe was used to identify sentinel nodes during surgery. A complete inguinofemoral node dissection was then performed. Sentinel nodes were submitted separately to pathologic evaluation. A total of 55 groins were dissected in 37 patients. Localization of the SN was successful in all cases. Eight cases had positive nodes: in all the sentinel node as positive; the sentinel node was the only positive node in five cases. Twenty-nine patients showed negative sentinel nodes: all of them were negative for lymph node metastases. Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance proved to be an easy and reliable method for the detection of sentinel node in early vulvar cancer. This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer. © 2000 Cancer Research Campaign

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363267

DOI: 10.1054/bjoc.1999.0918
PubMed: 10646880
PubMed Central: 2363267

Affiliations:

Italie

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This study evaluates the feasibility of the surgical identification of sentinel groin nodes using lymphoscintigraphy and a gamma-detecting probe in patients with early vulvar cancer. Technetium-99m-labelled colloid human albumin was administered perilesionally in 37 patients with invasive epidermoid vulvar cancer (T1–T2) and lymphoscintigraphy performed the day before surgery. An intraoperative gamma-detecting probe was used to identify sentinel nodes during surgery. A complete inguinofemoral node dissection was then performed. Sentinel nodes were submitted separately to pathologic evaluation. A total of 55 groins were dissected in 37 patients. Localization of the SN was successful in all cases. Eight cases had positive nodes: in all the sentinel node as positive; the sentinel node was the only positive node in five cases. Twenty-nine patients showed negative sentinel nodes: all of them were negative for lymph node metastases. Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance proved to be an easy and reliable method for the detection of sentinel node in early vulvar cancer. This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer.  © 2000 Cancer Research Campaign</p>
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Serveur d'exploration sur le lymphœdème

Sentinel node biopsy in early vulvar cancer

Sentinel node biopsy in early vulvar cancer

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Abstract

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